• Cell lines
• Primary cultures

Advantages:
•   Homogenous
•   Easy access/manipulation
•   Convenient for assays
•   HTS possible

Disadvantages:   
•   Single population
•   Lack interaction
•   Artifacts (O2A)

•   Organotypic slice culture

 Advantages:   
•   Mixed cell population
•   Easy access/manipulation
•   Convenient for assays  

Disadvantages:   
•   Preparation
•   Interpretation
•   HTS difficult